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Results for "

Natural Products，Cytotoxicity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Apoptosis (1) Endogenous Metabolite (2) Fungal (2) Hedgehog (1) HIV Integrase (1) Parasite (1)
By Research Areas:	Cancer (19) Infection (4) Inflammation/Immunology (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N8088

Neolancerin

Others Cancer

Neolancerin is a natural product with weak cytotoxic activity against HL-60 cells .

Neolancerin	Others	Cancer
Neolancerin is a natural product with weak cytotoxic activity against HL-60 cells .

HY-122948

Isogambogenic acid	Others	Cancer
Isogambogenic acid is a natural product that can be isolated from Resina Garciniae. Isogambogenic acid has cytotoxicity to cancer cell lines with IC₅₀ values of 0.4327-5.942 μmol/L .

HY-N8317

Rubicordifolin	Others	Cancer
Rubicordifolin is a natural product that can be isolated from Rubia cordifolia. Rubicordifolin inhibits the growth of sarcoma ascites in mice. Rubicordifolin has significant cytotoxic activity both in vitro and in vivo .

HY-136689

Taxin B

Others Cancer

Taxin B is a natural product with cytotoxicity effects .
HY-142007

Epothilone D1

Others Others

Epothilone D1 is an isolated natural product that shows cytotoxicity against mouse fibroblasts.
HY-N3430

Kaempferol tetraacetate

AF33
Others Cancer

Kaempferol tetraacetate (AF33) is a natural product. Kaempferol tetraacetate shows cytotoxicity .
HY-133220

Guajadial E

Others Cancer

Guajadial E is a natural product that can be found in Psidium guajava. Guajadial E shows cytotoxicity .
HY-133220A

Guajadial F

Others Cancer

Guajadial F is a natural product that can be found in Psidium guajava. Guajadial F shows cytotoxicity .

Taxin B	Others	Cancer
Taxin B is a natural product with cytotoxicity effects .

Epothilone D1	Others	Others
Epothilone D1 is an isolated natural product that shows cytotoxicity against mouse fibroblasts.

Kaempferol tetraacetate AF33	Others	Cancer
Kaempferol tetraacetate (AF33) is a natural product. Kaempferol tetraacetate shows cytotoxicity .

Guajadial E	Others	Cancer
Guajadial E is a natural product that can be found in Psidium guajava. Guajadial E shows cytotoxicity .

Guajadial F	Others	Cancer
Guajadial F is a natural product that can be found in Psidium guajava. Guajadial F shows cytotoxicity .

HY-N1266

Scutebata B	Others	Others
Scutebata B (compound 4) is a neoclerodane diterpenoid iaolated from the whole plant of Scutellaria barbata. Scutebata B has cytotoxic activities with IC₅₀ values of 10.27～28.48 μM .

HY-W010533

(E)-2-Methyl-2-pentenoic acid

Others Others

(E)-2-Methyl-2-pentenoic acid is the component can be used to synthesize the cytotoxic natural product Lactimidomycin .
HY-N1081A

Viteralone

(S)-Viteralone
Others Cancer

Viteralone (compound 5) is a natural product that can be isolated from Vitex negundo. Viteralone is cytotoxic to HL-60 cancer cells .
HY-133223

Hispidanin B

Others Cancer

Hispidanin B is a natural product that can be extracted from the rhizomes of Isodon hispida. Hispidanin B has cytotoxic activities against cancer cells .
HY-142102

T988C

(+)-T988C
Others Cancer

T988C is a heptacyclic epidithiodioxopiperazine (ETP) natural product. T988C shows strong cytotoxicity to cultured P388 leukemia cells .

(E)-2-Methyl-2-pentenoic acid	Others	Others
(E)-2-Methyl-2-pentenoic acid is the component can be used to synthesize the cytotoxic natural product Lactimidomycin .

Viteralone (S)-Viteralone	Others	Cancer
Viteralone (compound 5) is a natural product that can be isolated from Vitex negundo. Viteralone is cytotoxic to HL-60 cancer cells .

Hispidanin B	Others	Cancer
Hispidanin B is a natural product that can be extracted from the rhizomes of Isodon hispida. Hispidanin B has cytotoxic activities against cancer cells .

T988C (+)-T988C	Others	Cancer
T988C is a heptacyclic epidithiodioxopiperazine (ETP) natural product. T988C shows strong cytotoxicity to cultured P388 leukemia cells .

HY-117371

Hemiasterlin (-)-Hemiasterlin; Milnamide B	ADC Cytotoxin	Cancer
Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) .

HY-143242

Phidianidine B	Others	Others
Phidianidine B is a highly cytotoxic 1,2,4-oxadiazole marine metabolite. Phidianidine B is a natural product that can be isolated from a marine mollusk .

HY-N8679

Physalin C

Endogenous Metabolite Cancer

Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .

Physalin C	Endogenous Metabolite	Cancer
Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .

HY-N7933

Tetracosane ALKANE C24	Apoptosis	Inflammation/Immunology
Tetracosane (ALKANE C24) is a natural product that can be found in Acrostichum aureum. Tetracosane hows cytotoxicity and induces Apoptosis. Tetracosane has the potential for the research of peptic ulcer .

HY-N2852

α-Terthienylmethanol	Others	Others
α-Terthienylmethanol is a terthiophene isolated from the n-hexane fraction of E. prostrata. α-Terthienylmethanol has potent cytotoxic activity against human endometrial cancer cells (Hec1A and Ishikawa) (IC₅₀ < 1 μM). α-Terthienylmethanol increases the intracellular level of ROS and decreases that of GSH .

HY-N3916

Galanolactone (+)-Galanolactone	Fungal	Infection
Galanolactone is a natural product that can be isolated from the seeds of Alpinia galanga. Galanolactone shows antifungal activitie. Galanolactone shows cytotoxicity against KB cells with an EC₅₀ of 38.5 µg/ml .

HY-129148

Ganoderic acid AM1 GAAM1	Others	Cancer
Ganoderic acid AM1 (GAAM1) is a natural product that can be found in ganoderma lucidum. Ganoderic acid AM1 shows cytotoxicity with an IC₅₀ value of 19.8 µM for HeLa cells .

HY-N1912

Andropanolide
Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .

HY-N8846

dl-Aloesol	Fungal	Infection
dl-Aloesol is a natural product that can be isolated from fungus Aspergillus sp. Aspergillus sp metabolites has cytotoxic, antibacterial, free radical scavenging, anti-parasitic, antiviral and antiproliferative activities, etc .

HY-156186

Anticancer agent 160	Others	Cancer
Anticancer agent 160 (Compound 6) is a natural product derived from Parthenium hysterophorus. Anticancer agent 160 is cytotoxic to HCT-116 cells, IC₅₀=5.0 μM .

HY-156089

Triptoquinone H	Others	Inflammation/Immunology Cancer
Triptoquinone H is a class of natural product isolated from traditional Chinese medicine Tripterygium hypoglaucu. Triptoquinone H has strong cytotoxic, immunomodulatory and anti-inflammatory activities. Triptoquinone H can be used for cancer or inflammatory diseases research .

HY-N11519

Polyporusterone C	Others	Cancer
Polyporusterone C (Compound 3) is a natural product that can be isolated from Polyporus umbellatus. Polyporusterone C shows cytotoxic activities with IC₅₀s of 37, 26 and 42 μg/mL against L-1210 cells at 3, 5 and 7 days, respectively .

HY-N7173

7-Methoxy-β-carboline-1-propionic acid	Parasite	Infection
7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia .

HY-N3966

Goniodiol 8-acetate

Others Others

Goniodiol 8-acetate is a styrylpyrones that can be isolated from the leaves of Goniothalamus amuyon. Goniodiol 8-acetate has cytotoxic activity .

Goniodiol 8-acetate	Others	Others
Goniodiol 8-acetate is a styrylpyrones that can be isolated from the leaves of Goniothalamus amuyon. Goniodiol 8-acetate has cytotoxic activity .

HY-N11651

Peganumine A	Others	Others
Peganumine A is a natural product that can be found in Peganum harmala. Peganumine A shows cytotoxicity with IC₅₀s of5.8, 38.5, 40.2, 55.4 µM for HL-60, MCF-7, PC-3, and HepG2 cells ,respectively .

HY-N2228

(-)-Epigallocatechin-3-(3''-O-methyl) gallate (-)-EGCG-3''-O-ME
(-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3''-O-ME) is a natural product that can be isolated from the tea leaf, with strong antioxidative activity. (-)-Epigallocatechin-3-(3''-O-methyl) gallate has a strong cytotoxic activity for rat cancer cells .

HY-129144

Dihydrodehydrodiconiferyl alcohol	Others	Cancer
Dihydrodehydrodiconiferyl alcohol (compound 2) is a kind of neolignan. Dihydrodehydrodiconiferyl alcohol can be isolated from Anogeissus acuminata. Dihydrodehydrodiconiferyl alcohol has specific cytotoxic activity on melanoma cancer cell line .

HY-N12142

Anticancer agent 156	Others	Cancer
Anticancer agent 156 (compound 11) is a powerful anticancer agent based on Miliusanes (anticancer lead molecule). Anticancer agent 156 effectively inhibits the growth of human cancer cells and shows significant cytotoxicity to gastric cancer cells .

HY-N8270

Physalin H	Hedgehog Endogenous Metabolite	Cancer
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC₅₀ value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC₅₀ values of 5.7 and 6.8 μM, respectively .

HY-N6711

Equisetin	HIV Integrase	Infection
Equisetin is an N-methylserine-derived acyl tetramic acid isolated from a terrestrial fungus Fusarium equiseti NRRL 5537 . Equisetin is a tetramate-containing natural product with antibiotic and cytotoxic activity . Equisetin inhibits the growth of Gram-positive bacteria and HIV-1 integrase activity but shows no activity against Gram-negative bacteria . Equisetin is a Quorum-sensing inhibitor (QSI) that attenuates QS-regulated virulence phenotypes in P. aeruginosa without affecting the growth of bacterias, serves as a leading compound for the treatment of P. aeruginosa infections .

Neolancerin	other families Xanthones Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Others
Neolancerin is a natural product with weak cytotoxic activity against HL-60 cells .

Isogambogenic acid	Flavonoids Guttiferae Plants Garcinia hanburyi Hook. f. Other Flavonoids	Others
Isogambogenic acid is a natural product that can be isolated from Resina Garciniae. Isogambogenic acid has cytotoxicity to cancer cell lines with IC₅₀ values of 0.4327-5.942 μmol/L .

Rubicordifolin	Structural Classification Natural Products Source classification Rubiaceae Plants Rubia cordifolia L.	Others
Rubicordifolin is a natural product that can be isolated from Rubia cordifolia. Rubicordifolin inhibits the growth of sarcoma ascites in mice. Rubicordifolin has significant cytotoxic activity both in vitro and in vivo .

Taxin B	Structural Classification Terpenoids Source classification Taxaceae Diterpenoids Plants Taxus wallichiana var. mairei (Lemee & H. Léveillé) L. K. Fu & Nan Li	Others
Taxin B is a natural product with cytotoxicity effects .

Kaempferol tetraacetate AF33	Structural Classification Flavonoids Flavones Source classification Rosaceae Plants Fragaria × ananassa Duch.	Others
Kaempferol tetraacetate (AF33) is a natural product. Kaempferol tetraacetate shows cytotoxicity .

Guajadial E	Structural Classification Source classification Psidium guajava Linn. Phenols Polyphenols Myrtaceae Plants	Others
Guajadial E is a natural product that can be found in Psidium guajava. Guajadial E shows cytotoxicity .

Guajadial F	Structural Classification Other Monoterpenes Terpenoids Source classification Psidium guajava Linn. Myrtaceae Plants	Others
Guajadial F is a natural product that can be found in Psidium guajava. Guajadial F shows cytotoxicity .

Scutebata B	Structural Classification Terpenoids Labiatae Source classification Derris robusta Diterpenoids Plants	Others
Scutebata B (compound 4) is a neoclerodane diterpenoid iaolated from the whole plant of Scutellaria barbata. Scutebata B has cytotoxic activities with IC₅₀ values of 10.27～28.48 μM .

Viteralone (S)-Viteralone	Terpenoids Verbenaceae Sesquiterpenes Plants Vitex negundo Linn.	Others
Viteralone (compound 5) is a natural product that can be isolated from Vitex negundo. Viteralone is cytotoxic to HL-60 cancer cells .

Hispidanin B	Structural Classification Isodon hispidus (Bentham) Murata Terpenoids Labiatae Source classification Diterpenoids Plants	Others
Hispidanin B is a natural product that can be extracted from the rhizomes of Isodon hispida. Hispidanin B has cytotoxic activities against cancer cells .

Hemiasterlin (-)-Hemiasterlin; Milnamide B	Alkaloids Structural Classification Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Indole Alkaloids Cancer	ADC Cytotoxin
Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) .

Phidianidine B	Alkaloids Microorganisms Classification of Application Fields Marine natural products Other Diseases Disease Research Fields Marine microorganism	Others
Phidianidine B is a highly cytotoxic 1,2,4-oxadiazole marine metabolite. Phidianidine B is a natural product that can be isolated from a marine mollusk .

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Natural Products，Cytotoxicity

Inhibitors & Agonists

NaturalProducts

Natural
Products